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What is Bellafill?

Bellafill® (formerly known as Artefill) is the longest lasting dermal filler on the market. How does it last for up to five years, you might be wondering? The key is in the ingredients.

In this article, I’ll be discussing each of the ingredients in Bellafill®, breaking them down to the molecular level, and explaining how they work.

Polymethyl Methacrylate (PMMA) Microspheres

what is bellafill

Polymethyl methacrylate is a synthetic material that mimics resin. It is fully transparent and can be used in multiple products, including injectables such as Bellafill®.

For the purposes of this dermal filler, the PMMA has been formulated into microspheres, or extremely tiny 3-D circles. Your body sees the microspheres as a mild irritant, similar to the reaction that an oyster has to a grain of sand entering its shell.

With an oyster, the grain of sand prompts the mollusk to secrete a fluid that hardens around the sand…thus a pearl is formed. With a PMMA microsphere injected into the skin, the body is prompted to increase collagen production around the microspheres.

Collagen is an important component of youthful skin. It gives the skin pliability, flexibility, and strength. As we age, collagen production slows down and existing collagen is more easily broken down. The PMMA microspheres in Bellafill® help the body to replace collagen that was lost to the aging process.

This collagen BOOST can last for up to five years after injection, which helps to rebuild the collagen scaffolding (structure) for a more youthful appearance. Increased collagen also means that age-related facial volume loss can be corrected.

Bovine Collagen Gel Suspension

Bovine collagen comes from a cow, so if you’re allergic to beef or dairy, an allergy test on your forearm can help determine if you’re sensitive to Bellafill®. Generally, this allergy test is done at least 4 weeks prior to facial injections.

If you have a reaction to Bellafill®, it might look like redness, itching, or a rash. Most people do not have allergic reactions to the ingredients, but I always do an allergy test beforehand by injecting the product under the skin of the forearm.

Bovine collagen is soft and flexible, which can provide smooth-looking, natural volume wherever Bellafill® is injected. Over time, your body will metabolize and carry away the bovine collagen while the PMMA microspheres do their job by prompting your body to “fill in the gap” with new collagen in the treated areas.


Lidocaine is a local anesthetic that provides numbing so that injections are more comfortable. Patients can also request a topical numbing gel over the treatment areas.

Lidocaine is one of the local anesthetics used in dentistry, so you may have already experienced the pain-relieving benefits if you’ve had a cavity filled or a root canal performed.

When used in a dermal filler like Bellafill®, as soon as the product is injected, the lidocaine numbs the area on contact so that the procedure is more comfortable.

Sometimes, more than one visit is needed to achieve desired results, especially in larger areas like the cheeks. With lidocaine inside of the syringe, injections won’t hurt as much.

Get Bellafill® in San Diego at Beatitude Aesthetic Medicine

bellafill in san diego

Since 2008, I’ve been providing advanced cosmetic procedures that require very little to no downtime or discomfort…and no surgery.

Bellafill® is one of those products that works so well for everything from cheek volume restoration to filling in acne scars. Call me today at (619) 280-1609 to find out how this long-lasting filler can help you look and feel your best. Confidence is beautiful!

Other resources used for this article:

*Bellafill® is a registered trademark of Suneva Medical, Inc.


Patient Stories Dr. Chang has an eye for symmetry and aesthetics. I went in for a consultation to have fillers under my eyes. Instead I was educated on my facial anatomy. I agreed to some fillers in my forehead and cheeks instead and could not be more pleased with the outcome.
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